HEXADECYLPHOSPHOCHOLINE - PRECLINICAL AND THE 1ST CLINICAL-RESULTS OF A NEW ANTITUMOR DRUG

被引：55

作者：

UNGER, C

EIBL, H

机构：

[1] Division of Hematology/Oncology, Department of Internal Medicine, University Hospital Göttingen, Göttingen, D-3400

[2] Max-Planck-Institute for Biophysical Chemistry, Göttingen

来源：

LIPIDS | 1991年 / 26卷 / 12期

关键词：

D O I：

10.1007/BF02536578

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Dose-response studies on cytotoxic alkyl lysophospholipids with various chemical structures revealed that a long alkyl chain and a polar group are essential for antitumor activity. The combination of both the long alkyl chain and a phosphocholine group thus results in alkyl phosphocholines. Preclinical studies with hexadecylphosphocholine (He-PC) as a representative compound indicate distinct antineoplastic activity on leukemia cells of human origin. He-PC is highly effective in inhibiting the growth of chemically induced rat mammary carcinomas. Even more striking is the fact that a high percentage of the tumors regressed completely. In a clinical phase I trial on breast cancer patients with local recurrences, topically applied He-PC resulted in regression of skin metastases. A phase II trial for topical treatment and a phase I trial for orally applied He-PC have been initiated to further evaluate the antitumoral activity of this new compound.

引用

页码：1412 / 1417

页数：6

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