PHARMACOKINETICS OF N-NITRODIMETHYLAMINE AND N-NITROMETHYLAMINE IN THE RAT

被引：7

作者：

HASSEL, M ^{[1
]}

FREI, E ^{[1
]}

STREETER, AJ ^{[1
]}

WIESSLER, M ^{[1
]}

机构：

[1] NCI,FREDERICK CANC RES FACIL,FREDERICK,MD 21701

来源：

CARCINOGENESIS | 1990年 / 11卷 / 03期

关键词：

D O I：

10.1093/carcin/11.3.357

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Oxidative metabolism of radioactively labeled N-nitrodimethylamine in rats was compared with that of N-nitromethylamine. Within 7 h, 20% of N-nitrodimethylamine was metabolized to CO2 but only 4% of N-nitromethylamine. The poor oxidative metabolism of N-nitromethylamine is also reflected in the blood levels determined after i.v. administration to catheterized rats. N-nitrodimethylamine was cleared rapidly from rat blood, while N-nitromethylamine was rapidly distributed into body water but had a long elimination halflife. An amount equal to 5.2% of the dose of the monomethyl compound was excreted intact in urine, but only 0.004% of the dimethyl compound. The pharmacokinetic data obtained were compared with the published data on the pharmacokinetics of the structural analog N-nitrosodimethylamine. © 1990 Oxford University Press.

引用

页码：357 / 360

页数：4

共 19 条

[1] INFLUENCE OF A PROLONGED TREATMENT WITH DISULFIRAM AND D(-)PENICILLAMINE ON NITROSODIETHYLAMINE-INDUCED BIOLOGICAL AND BIOCHEMICAL EFFECTS IN RATS .1. INVESTIGATIONS ON THE DRUG-METABOLIZING SYSTEM [J].