AMPHOTROPIC MURINE LEUKEMIA RETROVIRUS IS NOT AN ACUTE PATHOGEN FOR PRIMATES

被引：145

作者：

CORNETTA, K

MOEN, RC

CULVER, K

MORGAN, RA

MCLACHLIN, JR

STURM, S

SELEGUE, J

LONDON, W

BLAESE, RM

ANDERSON, WF

机构：

[1] NHLBI,MOLEC HEMATOL LAB,BLDG 10,ROOM 7D-18,BETHESDA,MD 20892

[2] NCI,METAB BRANCH,CELLULAR IMMUNOL SECT,BETHESDA,MD 20892

[3] NINCDS,INFECT DIS BRANCH,EXPTL PATHOL SECT,BETHESDA,MD 20892

来源：

HUMAN GENE THERAPY | 1990年 / 1卷 / 01期

关键词：

D O I：

10.1089/hum.1990.1.1-15

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The in vivo fate of amphotropic murine leukemia retrovirus was studied in five rhesus monkeys. Retrovirus infused intravenously into 3 normal animals and 1 immunosuppressed animal was cleared rapidly from the circulation and subsequent viremia has not been detected (mean follow-up of 27.4 months). A fifth monkey was immunosuppressed and transplanted with virus-producing autologous fibroblasts in addition to an intraperitoneal injection of virus. This animal was viremic for 2 days and its lymph node cells and peripheral blood mononuclear cells were shown to be producing virus for up to 22 days post-inoculation, but subsequently has been negative after 17.0 months of analysis. In the 5 animals studied (combined mean follow-up of 25.7 months), clinical illness has not been identified at any time. Therefore, murine amphotropic retroviruses do not appear to pose an acute health risk.

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页码：15 / 30

页数：16

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