UNUSUAL SOLUBILITY BEHAVIOR OF CYCLOSPORINE-A IN AQUEOUS-MEDIA

被引：107

作者：

ISMAILOS, G

REPPAS, C

DRESSMAN, JB

MACHERAS, P

机构：

[1] UNIV ATHENS,DEPT PHARM,104 SOLONOS ST,GR-10680 ATHENS,GREECE

[2] UNIV MICHIGAN,COLL PHARM,ANN ARBOR,MI 48109

来源：

JOURNAL OF PHARMACY AND PHARMACOLOGY | 1991年 / 43卷 / 04期

关键词：

D O I：

10.1111/j.2042-7158.1991.tb06688.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The solubility of cyclosporin A was determined in water and in Sorensen buffers at pH 1.2 and 6.6 at temperatures ranging from 5 to 37-degrees-C. No differences in solubility behaviour were observed among the three aqeous media. Solubility was found to be inversely proportional to the temperature in each medium, indicating that the heat of solution was exothermic in each case.

引用

页码：287 / 289

页数：3

共 14 条

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