DIRECTING BROMINATION OF PIPERAZINE-2,5-DIONES

被引：17

作者：

BADRAN, TW

CHAI, CLL

EASTON, CJ

HARPER, JB

PAGE, DM

机构：

[1] UNIV ADELAIDE,DEPT CHEM,ADELAIDE,SA 5005,AUSTRALIA

[2] VICTORIA UNIV WELLINGTON,DEPT CHEM,WELLINGTON,NEW ZEALAND

来源：

AUSTRALIAN JOURNAL OF CHEMISTRY | 1995年 / 48卷 / 07期

关键词：

D O I：

10.1071/CH9951379

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

From intermolecular and intramolecular competition experiments, it has been established that, by comparison with an N-methyl substituent, an N-acetyl group deactivates glycine residues in piperazine-2,5-diones towards free-radical bromination. Combined with the ease of introduction and removal of N-acetyl substituents, the deactivating effect provides a method for regiocontrolled functionalization of these compounds.

引用

页码：1379 / 1384

页数：6

共 31 条

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