IMMUNOMODULATORY PROPERTIES OF CERTAIN AMINO-ACIDS INFLUENCE THE IMMUNOSTIMULATING PROPERTIES OF SPECIFIC PEPTIDES

被引:10
作者
BELOKRYLOV, GA [1 ]
MOLCHANOVA, IV [1 ]
SOROCHINSKAYA, EI [1 ]
机构
[1] AA ZHDANOV STATE UNIV,DEPT NAT COMP CHEM,LENINGRAD B-164,USSR
来源
INTERNATIONAL JOURNAL OF IMMUNOPHARMACOLOGY | 1990年 / 12卷 / 08期
关键词
D O I
10.1016/0192-0561(90)90003-6
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Using the previously obtained data that amino acids could influence the thymus-dependent immune response, the significance of amino acids in the immunostimulating activity of peptides has been studied. The effect of seven synthetic fragments of murine Thy-1 antigen, non-sulfated cholecystokinin (CCK-8), the two tetrapeptides at the N- and C-terminal fragments of CCK-8, as well as neurotensin (NT) have been investigated. It has been found that both NT and those Thy-1 fragments which consisted of immunologically inert amino acids, did not influence the immune response in mice. CCK-8, its C-terminal fragment and those Thy-1-antigen peptides which contained immunoactive amino acids at C- or N-terminus or both, stimulated IgM-plaque forming cells (PFC) in animals. The N-terminal CCK-8 tetrapeptide showed negligible activity. The possibility of the existence of two amino acids based and the other dependent upon a sequence of amino acids in the peptide is being discussed.
引用
收藏
页码:841 / 845
页数:5
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