AMIDE CHEMICAL-SHIFTS IN MANY HELICES IN PEPTIDES AND PROTEINS ARE PERIODIC

被引：86

作者：

KUNTZ, ID

KOSEN, PA

CRAIG, EC

机构：

[1] Department of Pharmaceutical Chemistry, University of California, California 94143-0446, San Francisco

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 1991年 / 113卷 / 04期

关键词：

D O I：

10.1021/ja00004a050

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A survey of the literature data on the NMR chemical shifts of amide hydrogens in peptides and proteins finds many cases in which resonances in helical structures show a periodicity of ca. 3-4 residues/cycle. Some helices do not show such behavior, nor do alpha-carbon hydrogen resonances. The simplest explanation is that the helical curvature found by high-resolution X-ray crystallographic studies for some helices in proteins is a fairly general phenomenon for protein and peptide structures in solution.

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页码：1406 / 1408

页数：3

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