N,N-DIISOPROPYL-BIS[2-(TRIMETHYLSILYL)ETHYL]PHOSPHORAMIDITE - AN ATTRACTIVE PHOSPHITYLATING AGENT COMPATIBLE WITH THE FMOC/T-BUTYL STRATEGY FOR THE SYNTHESIS OF PHOSPHOTYROSINE-CONTAINING PEPTIDES

被引:24
作者
CHAO, HG
BERNATOWICZ, MS
KLIMAS, CE
MATSUEDA, GR
机构
[1] Department of Macromolecular Biochemistry, Pharmaceutical Research Institute, Princeton, NJ 08543, Bristol Myers-Squibb
关键词
D O I
10.1016/S0040-4039(00)79160-X
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A new phosphitylating agent, compatible with the Fmoc/t-butyl strategy for the production of phosphotyrosine containing peptides was synthesized. Our results demonstrated that high yields and high purities of phosphotyrosine peptides can be obtained using this phosphitylating agent.
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页码:3377 / 3380
页数:4
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