N,N-DIISOPROPYL-BIS[2-(TRIMETHYLSILYL)ETHYL]PHOSPHORAMIDITE - AN ATTRACTIVE PHOSPHITYLATING AGENT COMPATIBLE WITH THE FMOC/T-BUTYL STRATEGY FOR THE SYNTHESIS OF PHOSPHOTYROSINE-CONTAINING PEPTIDES

被引：24

作者：

CHAO, HG

BERNATOWICZ, MS

KLIMAS, CE

MATSUEDA, GR

机构：

[1] Department of Macromolecular Biochemistry, Pharmaceutical Research Institute, Princeton, NJ 08543, Bristol Myers-Squibb

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 21期

关键词：

D O I：

10.1016/S0040-4039(00)79160-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new phosphitylating agent, compatible with the Fmoc/t-butyl strategy for the production of phosphotyrosine containing peptides was synthesized. Our results demonstrated that high yields and high purities of phosphotyrosine peptides can be obtained using this phosphitylating agent.

引用

页码：3377 / 3380

页数：4

共 24 条

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[22] 2-TRIMETHYLSILYLETHYL RESIDUE, A SELECTIVELY CLEAVABLE CARBOXYL PROTECTING GROUP
SIEBER, P
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[23] VALERIO RM, 1989, INT J PEPT PROT RES, V33, P428
[24] SYNTHESIS OF PHOSPHOTYROSYL-CONTAINING PHOSPHOPEPTIDES BY SOLID-PHASE PEPTIDE-SYNTHESIS
ZARDENETA, G
CHEN, D
WEINTRAUB, ST
KLEBE, RJ
[J]. ANALYTICAL BIOCHEMISTRY, 1990, 190 (02) : 340 - 347

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