N,N-DIISOPROPYL-BIS[2-(TRIMETHYLSILYL)ETHYL]PHOSPHORAMIDITE - AN ATTRACTIVE PHOSPHITYLATING AGENT COMPATIBLE WITH THE FMOC/T-BUTYL STRATEGY FOR THE SYNTHESIS OF PHOSPHOTYROSINE-CONTAINING PEPTIDES
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作者:
CHAO, HG
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机构:Department of Macromolecular Biochemistry, Pharmaceutical Research Institute, Princeton, NJ 08543, Bristol Myers-Squibb
CHAO, HG
BERNATOWICZ, MS
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机构:Department of Macromolecular Biochemistry, Pharmaceutical Research Institute, Princeton, NJ 08543, Bristol Myers-Squibb
BERNATOWICZ, MS
KLIMAS, CE
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机构:Department of Macromolecular Biochemistry, Pharmaceutical Research Institute, Princeton, NJ 08543, Bristol Myers-Squibb
KLIMAS, CE
MATSUEDA, GR
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机构:Department of Macromolecular Biochemistry, Pharmaceutical Research Institute, Princeton, NJ 08543, Bristol Myers-Squibb
MATSUEDA, GR
机构:
[1] Department of Macromolecular Biochemistry, Pharmaceutical Research Institute, Princeton, NJ 08543, Bristol Myers-Squibb
A new phosphitylating agent, compatible with the Fmoc/t-butyl strategy for the production of phosphotyrosine containing peptides was synthesized. Our results demonstrated that high yields and high purities of phosphotyrosine peptides can be obtained using this phosphitylating agent.