PREDISPOSITION TO RENAL-CELL CARCINOMA DUE TO ALTERATION OF A CANCER SUSCEPTIBILITY GENE

被引：79

作者：

WALKER, C

GOLDSWORTHY, TL

WOLF, DC

EVERITT, J

机构：

[1] Chemical Industry Institute of Toxicology, Research Triangle Park, NC 27709

来源：

SCIENCE | 1992年 / 255卷 / 5052期

关键词：

D O I：

10.1126/science.1553556

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A single germ line gene mutation at a tumor susceptibility locus in a rodent model of hereditary human renal cancer caused a 70-fold increase in susceptibility to chemical carcinogenesis. A carcinogen that targeted both renal epithelial and mesenchymal cells caused an increase in tumors of epithelial origin in susceptible animals; the number of carcinogen-induced mesenchymal tumors was unaffected by the presence of the mutation at the susceptibility locus. Thus, this mutation defines a genetic locus for susceptibility to carcinogen-induced tumors and modulation of carcinogen susceptibility by this locus exhibits cell-type specificity.

引用

页码：1693 / 1695

页数：3

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