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THE ROLE OF CHROMOSOME TRANSLOCATIONS IN T-CELL ACUTE-LEUKEMIA

被引：26
作者：
HWANG, LY
BAER, RJ
机构：
[1] Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX 752359-9140
来源：
CURRENT OPINION IN IMMUNOLOGY | 1995年 / 7卷 / 05期
关键词：
D O I：
10.1016/0952-7915(95)80074-3
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
A variety of unique chromosome translocations are found in the malignant cells of patients with T cell acute lymphoblastic leukemia (T-ALL). Molecular analysis of these translocations has implicated nine different proto-oncogenes in the pathogenesis of T-ALL. Despite the apparent genetic complexity of this disease, recent studies have uncovered a common pathway of T-ALL development that involves two distinct families of transcription factors.
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页码：659 / 664
页数：6
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