THE ROLE OF CHROMOSOME TRANSLOCATIONS IN T-CELL ACUTE-LEUKEMIA

被引：26

作者：

HWANG, LY

BAER, RJ

机构：

[1] Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX 752359-9140

来源：

CURRENT OPINION IN IMMUNOLOGY | 1995年 / 7卷 / 05期

关键词：

D O I：

10.1016/0952-7915(95)80074-3

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A variety of unique chromosome translocations are found in the malignant cells of patients with T cell acute lymphoblastic leukemia (T-ALL). Molecular analysis of these translocations has implicated nine different proto-oncogenes in the pathogenesis of T-ALL. Despite the apparent genetic complexity of this disease, recent studies have uncovered a common pathway of T-ALL development that involves two distinct families of transcription factors.

引用

页码：659 / 664

页数：6

共 54 条

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