TRANSCRIPTIONAL REGULATION OF THE ADRENAL STEROIDOGENIC ENZYMES

被引:56
作者
PARKER, KL
SCHIMMER, BP
机构
[1] DUKE UNIV,MED CTR,HOWARD HUGHES MED INST,DURHAM,NC 27710
[2] DUKE UNIV,MED CTR,DEPT BIOCHEM,DURHAM,NC 27710
[3] UNIV TORONTO,BANTING & BEST DEPT MED RES,TORONTO M5S 1A1,ONTARIO,CANADA
基金
英国医学研究理事会;
关键词
D O I
10.1016/S1043-2760(05)80014-1
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Corticosteroid biosynthesis requires the concerted action of a related group of cytochrome P450 steroid hydroxylases. The genes encoding these steroid hydroxylases exhibit two distinct levels of transcriptional regulation: selective expression in steroidogenic cells and induction in response to trophic hormones. With respect to cell-selective expression, recent studies have identified a nuclear receptor protein expressed only in steroidogenic cells that is postulated to regulate the expression of all cytochrome P450 steroid hydroxylases through common promoter elements. In contrast, the coordinate responses of these genes to trophic hormones are not readily explained by a unifying mechanism, and their hormone responsive expression probably involves multiple promoter elements.
引用
收藏
页码:46 / 50
页数:5
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