2 SYNTHESES OF MANOALIDE VIA HETEROATOM-ASSISTED ALKYNE CARBOMETALLATION

被引：43

作者：

BURY, P

HAREAU, G

KOCIENSKI, P

DHANAK, D

机构：

[1] UNIV SOUTHAMPTON,DEPT CHEM,SOUTHAMPTON SO17 1BJ,HANTS,ENGLAND

[2] SMITHKLINE BEECHAM PHARMACEUT,FRYTHE,WELWYN GARDEN CIT AL6 9AR,HERTS,ENGLAND

来源：

TETRAHEDRON | 1994年 / 50卷 / 29期

关键词：

D O I：

10.1016/S0040-4020(01)85353-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two approaches to the sesterterpenoid phospholipase A(2) inhibitors seco-manoalide (3) and manoalide (1) are described based on carbometallation of propargylic alcohols to generate the functionalised C6-C7 trisubstituted alkene. Both syntheses also deploy the photooxidation of a furan in order to generate a 4-substituted-5-hydroxy-2(5H)-furanone moiety.

引用

页码：8793 / 8808

页数：16

共 46 条

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