METALATION OF DIAZINES .4. LITHIATION OF SYM-DISUBSTITUTED PYRAZINES

被引：35

作者：

TURCK, A ^{[1
]}

TROHAY, D ^{[1
]}

MOJOVIC, L ^{[1
]}

PLE, N ^{[1
]}

QUEGUINER, G ^{[1
]}

机构：

[1] INST NATL SCI APPL,IRCOF,CHIM ORGAN FINE & HETEROCYCL LAB,URA 1429,BP 08,F-76131 MT ST AIGNAN,FRANCE

来源：

JOURNAL OF ORGANOMETALLIC CHEMISTRY | 1991年 / 412卷 / 03期

关键词：

DIRECTED LITHIATION;

D O I：

10.1016/0022-328X(91)86074-Z

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Conditions for the metalation of 2,6-dichloro- and 2,6-dimethoxy-pyrazine are defined and the lithio-derivatives are shown to react with some electrophiles. A convenient synthesis of a diazaxanthone from the lithio-derivative of the dichloro-compound is described. Couplings between phenylacetylene and iodo-derivatives of pyrazine have been carried out.

引用

页码：301 / 310

页数：10

共 6 条

[1] ORTHO-DIRECTED LITHIATION IN PI-DEFICIENT DIAZINYL HETEROCYCLES
MATTSON, RJ
SLOAN, CP
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1990, 55 (10) : 3410 - 3412
[2] METALATION OF DIAZINES .3. NEW SYNTHESIS OF ANALOGS OF TRIMETHOPRIM AND OF BACIMETHRIN
PLE, N
TURCK, A
FIQUET, E
QUEGUINER, G
[J]. JOURNAL OF HETEROCYCLIC CHEMISTRY, 1991, 28 (02) : 283 - 287
[3] ROYER R, 1968, B SOC CHIM FR, P2633
[4] METALATION OF DIAZINES .2. 1ST METALATION OF PYRIDAZINE, METALATION OF 2,4-DICHLOROPYRIMIDINE
TURCK, A
PLE, N
MOJOVIC, L
QUEGUINER, G
[J]. JOURNAL OF HETEROCYCLIC CHEMISTRY, 1990, 27 (05) : 1377 - 1381
[5] TURCK A, 1988, SYNTHESIS-STUTTGART, V11, P881
[6] SYNTHESIS OF BOSTRYCOIDIN VIA DIRECTED LITHIATION OF TERTIARY NICOTINAMIDE
WATANABE, M
SHINODA, E
SHIMIZU, Y
FURUKAWA, S
IWAO, M
KURAISHI, T
[J]. TETRAHEDRON, 1987, 43 (22) : 5281 - 5286

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