HB GRAZ OR ALPHA-2-BETA-22(NA2)HIS-]LEU - A NEW BETA-CHAIN VARIANT OBSERVED IN 4 FAMILIES FROM SOUTHERN AUSTRIA

被引：18

作者：

LIU, JS

MOLCHANOVA, TP

GU, LH

WILSON, JB

HOPMEIER, P

SCHNEDL, W

BALAUN, E

KREJS, GJ

HUISMAN, THJ

机构：

[1] KRANKENANSTALT RUDOLFSTIFTUNG WIEN,CENT LAB,A-1030 VIENNA,AUSTRIA

[2] GRAZ UNIV,DEPT MED,A-8036 GRAZ,AUSTRIA

来源：

HEMOGLOBIN | 1992年 / 16卷 / 06期

关键词：

D O I：

10.3109/03630269208993117

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Two abnormal hemoglobins were accidentally detected by cation exchange high performance liquid chromatography with the Diamat system of Bio-Rad Laboratories; the variants eluted together with the fast-moving Hb A1c. Structural analysis of isolated beta chains and sequence analysis of amplified DNA identified a new variant, i.e. Hb Graz that has a His-->Leu replacement at position 2 of the beta chain, in four healthy, apparently unrelated, adults. The second variant was identical to Hb Sherwood Forest or alpha2beta(2)104(G6)Arg-->Thr; it is believed that this may be the second observation of this abnormal hemoglobin.

引用

页码：493 / 501

页数：9

共 17 条

[1] HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC SEPARATION OF HUMAN HEMOGLOBINS - SIMULTANEOUS QUANTITATION OF FETAL AND GLYCATED HEMOGLOBINS [J].