DETECTION OF CLENBUTEROL RESIDUES IN HAIR

被引:35
作者
ADAM, A
GERVAIS, N
PANOYAN, A
ONG, H
BELIVEAU, L
AYOTTE, C
DELAHAUT, P
机构
[1] UNIV MONTREAL,DEPT EDUC PHYS,MONTREAL,PQ H3C 3J7,CANADA
[2] INST NATL RECH SCI SANTE,POINTE CLAIRE,PQ H9R 1G6,CANADA
[3] CER,HORMONOL LAB,B-6900 MARLOIE,BELGIUM
关键词
CLENBUTEROL; BETA(2)-AGONIST RESIDUE; ENZYME IMMUNOASSAY; HAIR ANALYSIS;
D O I
10.1039/an9941902663
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
Sixty rats were grown in the presence of 10 (n = 30) and 100 (n = 30) pg kg(-1) body mass of clenbuterol for a period of 10 d, An immunoextraction step coupled with a competitive enzyme immunoassay allowed the quantification of clenbuterol in hair upon 20 (10 mu g kg(-1)) and 30 d (100 mu g kg(-1)) after the last dose. This accumulation in hair contrasts with the rapid clearance in tissues. The nature of the immunoreactive material was confirmed by mass spectrometry.
引用
收藏
页码:2663 / 2666
页数:4
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