THE NEUROPATHOLOGY OF SCHIZOPHRENIA - A CRITICAL-ASSESSMENT OF RESEARCH METHODOLOGIES

被引：16

作者：

CASANOVA, MF

KLEINMAN, JE

机构：

[1] NATL INST MENTAL HLTH, CLIN BRAIN DISORDERS BRANCH, WASHINGTON, DC USA

[2] JOHNS HOPKINS UNIV, SCH MED, DEPT PATHOL, BALTIMORE, MD 21205 USA

[3] JOHNS HOPKINS UNIV, SCH MED, NEUROPATHOL LAB, BALTIMORE, MD 21205 USA

来源：

BIOLOGICAL PSYCHIATRY | 1990年 / 27卷 / 03期

关键词：

D O I：

10.1016/0006-3223(90)90009-Q

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Modern neuropathology has been the recipient of several high-powered quantitative analytical techniques. If properly applied, these techniques provide experimental results with high inter-rater reliability and scientific validity. However, inadvergent methodological problems can be the cause of some of the conflicting results in the schizophrenia research literature. In the present article, we discuss some of the inconsistencies reported in the recent literature and provide suggestions for improving tissue retrieval, selection of anatomical levels, neuronal counts, and neuronometry. We emphasize the importance of shrinkage correction for individual brains and suggest caution in the interpretation of immunocytochemistry and computerized image analysis studies. © 1990.

引用

页码：353 / 362

页数：10

共 47 条

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