SIDEROPHORE ANALOGS - SYNTHESIS AND CHELATING PROPERTIES OF A NEW MACROCYCLIC TRISHYDROXAMATE LIGAND

被引:34
作者
ESTEVES, MA
VAZ, MCT
GONCALVES, MLSS
FARKAS, E
SANTOS, MA
机构
[1] INST SUPER TECN,CTR QUIM ESTRUTURAL,P-1096 LISBON,PORTUGAL
[2] UNIV DEBRECEN,DEPT INORGAN & ANALYT CHEM,H-4010 DEBRECEN,HUNGARY
来源
JOURNAL OF THE CHEMICAL SOCIETY-DALTON TRANSACTIONS | 1995年 / 15期
关键词
D O I
10.1039/dt9950002565
中图分类号
O61 [无机化学];
学科分类号
070301 ; 081704 ;
摘要
A new iron(III)-specific ligand, 1,5,9-triazacyclododecane-N,N',N''-tris(N'-methylacetohydroxamic acid) H(3)L, containing three hydroxamic acid groups as pendant arms on a macrocyclic triamine backbone, has been synthesized and characterized. Its acid-base and chelating properties with iron(III) and copper(II) ions have been studied by potentiometric and spectrophotometric techniques. The mechanism of electron transfer as well as the kinetics of dissociation and stability constants of reduced species, which are thought to be important in the biological activity of this siderophore analogue, have been studied by voltammetric methods. This ligand has proved to be biologically active and its properties were compared with ferrichrome and ferrioxamine B.
引用
收藏
页码:2565 / 2573
页数:9
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