SEROTONIN DEPLETORS, 5,7-DIHYDROXYTRYPTAMINE AND P-CHLOROPHENYLALANINE, CAUSE SPROUTING IN THE CNS OF THE ADULT SNAIL

被引：26

作者：

BAKER, MW

VOHRA, MM

CROLL, RP

机构：

[1] DALHOUSIE UNIV, DEPT PHYSIOL & BIOPHYS, HALIFAX B3H 4H7, NS, CANADA

[2] DALHOUSIE UNIV, DEPT PHARMACOL, HALIFAX B3H 4H2, NS, CANADA

来源：

BRAIN RESEARCH | 1993年 / 623卷 / 02期

基金：

加拿大自然科学与工程研究理事会;

关键词：

GASTROPOD; NEURAL OUTGROWTH; FEEDING; LEARNING; BEHAVIOR;

D O I：

10.1016/0006-8993(93)91444-W

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effects of 5,7-dihydroxytryptamine (5,7-DHT) and p-chlorophenylalanine (PCPA) on neuronal morphology were investigated in Achatina fulica by backfilling the cerebrobuccal connective with nickel-lysine. Backfilling 21 days following injections of either 5,7-DHT or PCPA revealed supernumerary staining of fibers in different pathways of the cerebral and buccal ganglia and novel staining of somata in the cerebral ganglia. HPLC measurements confirm that drug treatments led to a 30-46% depletion of serotonin (5-HT) in the buccal ganglia. These results support the role suggested for 5-HT as a neuritogenic modulator and additionally advise caution in the use of pharmacological depletors in studies examining serotonergic function.

引用

页码：311 / 315

页数：5