QUANTITATIVE-ANALYSIS OF THE OLFACTORY PATHWAY FOR DRUG-DELIVERY TO THE BRAIN

被引：264

作者：

THORNE, RG ^{[1
]}

EMORY, CR ^{[1
]}

ALA, TA ^{[1
]}

FREY, WH ^{[1
]}

机构：

[1] UNIV MINNESOTA,ST PAUL RAMSEY MED CTR,DEPT NEUROL,RAMSEY CLIN,ST PAUL,MN 55101

来源：

BRAIN RESEARCH | 1995年 / 692卷 / 1-2期

关键词：

INTRANASAL; OLFACTORY BULB; PROTEIN TRANSPORT; DRUG DELIVERY; ALZHEIMERS DISEASE;

D O I：

10.1016/0006-8993(95)00637-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Following intranasal administration to rats, wheat germ agglutinin-horseradish peroxidase (WGA-HRP) concentrated in the olfactory nerve and glomerular layers of the olfactory bulb resulting in a mean olfactory bulb concentration of 140 nM. A negligible amount of label was detected in the olfactory bulb following intravenous administration of WGA-HRP or intranasal administration of unconjugated HRP. This is the first quantitative assessment of intraneuronal transport of a protein into the brain using the olfactory route.

引用

页码：278 / 282

页数：5

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