QUANTITATIVE-ANALYSIS OF THE OLFACTORY PATHWAY FOR DRUG-DELIVERY TO THE BRAIN

被引：264

作者：

THORNE, RG ^{[1
]}

EMORY, CR ^{[1
]}

ALA, TA ^{[1
]}

FREY, WH ^{[1
]}

机构：

[1] UNIV MINNESOTA,ST PAUL RAMSEY MED CTR,DEPT NEUROL,RAMSEY CLIN,ST PAUL,MN 55101

来源：

BRAIN RESEARCH | 1995年 / 692卷 / 1-2期

关键词：

INTRANASAL; OLFACTORY BULB; PROTEIN TRANSPORT; DRUG DELIVERY; ALZHEIMERS DISEASE;

D O I：

10.1016/0006-8993(95)00637-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Following intranasal administration to rats, wheat germ agglutinin-horseradish peroxidase (WGA-HRP) concentrated in the olfactory nerve and glomerular layers of the olfactory bulb resulting in a mean olfactory bulb concentration of 140 nM. A negligible amount of label was detected in the olfactory bulb following intravenous administration of WGA-HRP or intranasal administration of unconjugated HRP. This is the first quantitative assessment of intraneuronal transport of a protein into the brain using the olfactory route.

引用

页码：278 / 282

页数：5

共 25 条

[21] LABELING OF OLFACTORY-BULB GLOMERULI FOLLOWING HORSERADISH-PEROXIDASE LAVAGE OF THE NASAL CAVITY [J].

STEWART, WB .

BRAIN RESEARCH, 1985, 347 (01) :200-203

[22] THE SPATIAL-ORGANIZATION OF OLFACTORY NERVE PROJECTIONS [J].

STEWART, WB ;

PEDERSEN, PE .

BRAIN RESEARCH, 1987, 411 (02) :248-258

[23] PATHOLOGICAL-CHANGES IN OLFACTORY NEURONS IN PATIENTS WITH ALZHEIMERS-DISEASE [J].

TALAMO, BR ;

RUDEL, RA ;

KOSIK, KS ;

LEE, VMY ;

NEFF, S ;

ADELMAN, L ;

KAUER, JS .

NATURE, 1989, 337 (6209) :736-739

[24]

THORNE R G, 1992, Neurobiology of Aging, V13, pS132

[25] CONJUGATES OF HORSERADISH-PEROXIDASE (HRP) WITH CHOLERA-TOXIN AND WHEAT-GERM-AGGLUTININ ARE SUPERIOR TO FREE HRP AS ORTHOGRADELY TRANSPORTED MARKERS [J].

TROJANOWSKI, JQ ;

GONATAS, JO ;

GONATAS, NK .

BRAIN RESEARCH, 1981, 223 (02) :381-385

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