WHAT TO DO AT AN END - DNA DOUBLE-STRAND-BREAK REPAIR

被引：183

作者：

WEAVER, DT ^{[1
]}

机构：

[1] HARVARD UNIV, SCH MED, DEPT MICROBIOL & MOLEC GENET, BOSTON, MA 02115 USA

来源：

TRENDS IN GENETICS | 1995年 / 11卷 / 10期

关键词：

D O I：

10.1016/S0168-9525(00)89121-0

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Repairing chromosome breaks is essential to cell survival. A major lethal effect of ionizing radiation (IR) damage is the creation of double-strand DNA breaks. Recently, a number of mammalian cell mutants that are sensitive to IR damage have been described, revealing a unique repair pathway. The DNA-dependent protein kinase (DNA-PK) is necessary for double-strand-break repair and lymphoid V(D)J recombination. DNA-PK consists of three subunits: the Ku autoantigen heterodimer and a kinase (DNA-PKcs) that is deficient in mouse scid mutant cells.

引用

页码：388 / 392

页数：5

共 51 条

[1] DNA-DAMAGE AND THE DNA-ACTIVATED PROTEIN-KINASE [J].

ANDERSON, CW .

TRENDS IN BIOCHEMICAL SCIENCES, 1993, 18 (11) :433-437

[2] COMPLEMENTATION OF V(D)J RECOMBINATION DEFECT AND X-RAY-SENSITIVITY OF SCID MOUSE CELLS BY HUMAN-CHROMOSOME-8 [J].

BANGA, SS ;

HALL, KT ;

SANDHU, AK ;

WEAVER, DT ;

ATHWAL, RS .

MUTATION RESEARCH-DNA REPAIR, 1994, 315 (03) :239-247

[3] A DROSOPHILA PROTEIN HOMOLOGOUS TO THE HUMAN P70 KU AUTOIMMUNE ANTIGEN INTERACTS WITH THE P-TRANSPOSABLE ELEMENT INVERTED REPEATS [J].

BEALL, EL ;

ADMON, A ;

RIO, DC .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (26) :12681-12685

[4] SCID MUTATION IN MICE CONFERS HYPERSENSITIVITY TO IONIZING-RADIATION AND A DEFICIENCY IN DNA DOUBLE-STRAND BREAK REPAIR [J].

BIEDERMANN, KA ;

SUN, JR ;

GIACCIA, AJ ;

TOSTO, LM ;

BROWN, JM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (04) :1394-1397

[5] DEFECTIVE DNA-DEPENDENT PROTEIN-KINASE ACTIVITY IS LINKED TO V(D)J RECOMBINATION AND DNA-REPAIR DEFECTS ASSOCIATED WITH THE MURINE SCID MUTATION [J].

BLUNT, T ;

FINNIE, NJ ;

TACCIOLI, GE ;

SMITH, GCM ;

DEMENGEOT, J ;

GOTTLIEB, TM ;

MIZUTA, R ;

VARGHESE, AJ ;

ALT, FW ;

JEGGO, PA ;

JACKSON, SP .

CELL, 1995, 80 (05) :813-823

[6] COMPLEMENTATION OF THE IONIZING-RADIATION SENSITIVITY, DNA END BINDING, AND V(D)J RECOMBINATION DEFECTS OF DOUBLE-STRAND BREAK REPAIR MUTANTS BY THE P86 KU AUTOANTIGEN [J].

BOUBNOV, NV ;

HALL, KT ;

WILLS, Z ;

LEE, SE ;

HE, DM ;

BENJAMIN, DM ;

PULASKI, CR ;

BAND, H ;

REEVES, W ;

HENDRICKSON, EA ;

WEAVER, DT .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (03) :890-894

[7]

BOUBNOV NV, IN PRESS MOL CELL BI

[8] CHROMOSOMAL LOCATION AND EXPRESSION OF THE GENES-CODING FOR KU P70 AND P80 IN HUMAN CELL-LINES AND NORMAL-TISSUES [J].

CAI, QQ ;

PLET, A ;

IMBERT, J ;

LAFAGEPOCHITALOFF, M ;

CERDAN, C ;

BLANCHARD, JM .

CYTOGENETICS AND CELL GENETICS, 1994, 65 (04) :221-227

[9] ROLE OF A MAJOR AUTOEPITOPE IN FORMING THE DNA-BINDING SITE OF THE P70 (KU) ANTIGEN [J].

CHOU, CH ;

WANG, JS ;

KNUTH, MW ;

REEVES, WH .

JOURNAL OF EXPERIMENTAL MEDICINE, 1992, 175 (06) :1677-1684

[10] RESCUE OF T-CELL-SPECIFIC V(D)J RECOMBINATION IN SCID MICE BY DNA-DAMAGING AGENTS [J].

DANSKA, JS ;

PFLUMIO, F ;

WILLIAMS, CJ ;

HUNER, O ;

DICK, JE ;

GUIDOS, CJ .

SCIENCE, 1994, 266 (5184) :450-455

← 1 2 3 4 5 6 →