BIOMATERIALS FOR BLOOD-CONTACTING APPLICATIONS

被引：194

作者：

COURTNEY, JM ^{[1
]}

LAMBA, NMK ^{[1
]}

SUNDARAM, S ^{[1
]}

FORBES, CD ^{[1
]}

机构：

[1] NINEWELLS HOSP & MED SCH, DEPT MED, DUNDEE DD1 95Y, SCOTLAND

来源：

BIOMATERIALS | 1994年 / 15卷 / 10期

基金：

英国医学研究理事会;

关键词：

BIOMATERIALS; BLOOD-BIOMATERIAL INTERACTIONS; EVALUATION;

D O I：

10.1016/0142-9612(94)90026-4

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Consideration of biomaterials for blood-contacting applications should take into account blood-biomaterial interactions, factors influencing the blood response and evaluation procedures. Examination of blood-biomaterial interactions indicates that relevant features are protein adsorption, platelet reactions, intrinsic coagulation, fibrinolytic activity, erythrocytes, leucocytes and complement activation. Factors influencing the blood response to a biomaterial in clinical application are the biomaterial structure, the presence of an antithrombotic agent, the patient status as determined by the disease and drug therapy, and the nature of the application. Evaluation options for biomaterials are clinical, in vivo, ex vivo and in vitro, with ex vivo and in vitro procedures relevant for biomaterial development.

引用

页码：737 / 744

页数：8

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