LOCALIZATION OF THE GENE ENCODING R-KAPPA-B (NFRKB), A TISSUE-SPECIFIC DNA-BINDING PROTEIN, TO CHROMOSOME-11Q24-Q25

被引：10

作者：

ADAMS, BS

LEUNG, K

MELTZER, PS

LEWIS, KA

WAGNERMCPHERSON, C

EVANS, GA

NABEL, GJ

机构：

[1] UNIV MICHIGAN,MED CTR,HOWARD HUGHES MED INST,DEPT INTERNAL MED,ANN ARBOR,MI 48109

[2] UNIV MICHIGAN,MED CTR,HOWARD HUGHES MED INST,DEPT BIOL CHEM,ANN ARBOR,MI 48109

[3] UNIV MICHIGAN,MED CTR,DEPT RADIAT ONCOL,ANN ARBOR,MI 48109

[4] SALK INST BIOL STUDIES,MOLEC GENET LAB,LA JOLLA,CA 92037

来源：

GENOMICS | 1992年 / 14卷 / 02期

关键词：

D O I：

10.1016/S0888-7543(05)80216-2

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Although NF (nuclear factor)-κB binds in vitro to several of the κB regulatory elements found in cellular and viral genes, another DNA binding protein, RκB, also binds to a related variant of the κB site that regulates interleukin-2 receptor α-chain gene expression, a critical event in T cell activation. Southern blot analysis of a human-mouse somatic cell hybrid panel and in situ hybridization using a fluorescent genomic RκB probe have allowed assignment of the RκB gene (NFRKB) to 11q24-q25. The NFRKB locus is in close proximity to the chromosomal breakpoint implicated in Ewing sarcoma, but it does not appear to span this region. Nonetheless, NFRKB may be particularly useful as the most telomeric marker thus far assigned to 11q. © 1992 Academic Press, Inc. All rights reserved.

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页码：270 / 274

页数：5

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