IN-VITRO ANTIPLASMODIAL EFFECTS OF DIOSPYRIN, A PLANT-DERIVED NAPHTHOQUINOID, AND A NOVEL SERIES OF DERIVATIVES

被引：29

作者：

HAZRA, B

GHOSH, R

BANERJEE, A

KIRBY, GC

WARHURST, DC

PHILLIPSON, JD

机构：

[1] UNIV LONDON LONDON SCH HYG & TROP MED,DEPT MED PARASITOL,LONDON WC1E 7HT,ENGLAND

[2] JADAVPUR UNIV,DEPT PHARM,CALCUTTA 700032,W BENGAL,INDIA

[3] JADAVPUR UNIV,DEPT CHEM,CALCUTTA 700032,W BENGAL,INDIA

[4] UNIV LONDON,SCH PHARM,DEPT PHARMACOGNOSY,LONDON WC1N 1AX,ENGLAND

来源：

PHYTOTHERAPY RESEARCH | 1995年 / 9卷 / 01期

关键词：

MALARIA CHEMOTHERAPY; IN VITRO ANTIPLASMODIAL ACTIVITY; PLASMODIUM FALCIPARUM; DIOSPYROS MONTANA ROXB; NAPHTHOQUINOIDS; HYDROQUINOIDS;

D O I：

10.1002/ptr.2650090118

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Synthesis of derivatives of diospyrin, a natural product, has led to the modification of its tumour-inhibitory effect, in vitro, towards Ehrlich ascites carcinoma and antiparasitic activity against Leishmania donovani in vitro, The present study shows that two of these novel hydroquinoid analogues derived from diospyrin also show enhanced inhibitory effects against Plasmodium falciparum, in vitro, and may be a useful model for the development of novel antimalarial drugs.

引用

页码：72 / 74

页数：3

共 15 条

[1] INVITRO ANTIMALARIAL AND CYTOTOXIC ACTIVITIES OF SEMISYNTHETIC DERIVATIVES OF BRUSATOL [J].