PERGOLIDE CAN INDUCE SOLUBLE SUPEROXIDE-DISMUTASE IN RAT STRIATA

被引：28

作者：

CLOW, A

HUSSAIN, T

GLOVER, V

SANDLER, M

WALKER, M

DEXTER, D

机构：

[1] QUEEN CHARLOTTES & CHELSEA HOSP, DEPT CHEM PATHOL, LONDON, ENGLAND

[2] UNIV LONDON KINGS COLL, DEPT PHARMACOL, LONDON WC2R 2LS, ENGLAND

来源：

JOURNAL OF NEURAL TRANSMISSION-GENERAL SECTION | 1992年 / 90卷 / 01期

关键词：

SUPEROXIDE DISMUTASE; PARKINSONS DISEASE; (-)-DEPRENYL; PERGOLIDE; DOPAMINE;

D O I：

10.1007/BF01250515

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Pergolide, a dopamine receptor agonist, given daily i.p. for three weeks at 0.04 mg/kg and 0.4 mg/kg, significantly induced soluble (Cu-Zn) superoxide dismutase in the rat striatum, while having no effect on the mitochondrial (Mn) form of the enzyme. Such induction, which can also be effected by (-)-deprenyl, may help to protect against nigrostriatal degeneration.

引用

页码：27 / 31

页数：5

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