COMPARISON OF CYTOTOXICITY OF THE (-)-ENANTIOMER AND (+)-ENANTIOMER OF 2',3'-DIDEOXY-3'-THIACYTIDINE IN NORMAL HUMAN BONE-MARROW PROGENITOR CELLS

被引：48

作者：

SOMMADOSSI, JP

SCHINAZI, RF

CHU, CK

XIE, MY

机构：

[1] VETERANS AFFAIRS MED CTR,DECATUR,GA 30033

[2] UNIV ALABAMA,DIV CLIN PHARMACOL,BIRMINGHAM,AL 35294

[3] EMORY UNIV,SCH MED,DEPT PEDIAT,BIOCHEM PHARMACOL LAB,ATLANTA,GA 30322

[4] UNIV GEORGIA,COLL PHARM,DEPT MED CHEM & PHARMACOGNOSY,ATHENS,GA 30602

来源：

BIOCHEMICAL PHARMACOLOGY | 1992年 / 44卷 / 10期

关键词：

D O I：

10.1016/0006-2952(92)90093-X

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The effects of racemic cis-2',3'-dideoxy-3'-thiacytidine [(+/-)-BCH-189] and its two enantiomers on human myeloid and erythroid colony-forming cells were studied by clonogenic assays. The (+)-isomer was the most toxic with a median inhibitory concentration approximating 2 muM in both cell lineages. In contrast concentrations of the (-)-isomer required for 50% inhibition of granulocyte macrophage colony-forming units (CFU-GM) and erythroid burst-forming units (BFU-E) were 33.9 +/- 15.1 and 169.4 +/- 87.9 muM, respectively. The racemic BCH-189 was quite toxic to these cells, but to a lesser extent than observed with 3'-azido-3'-deoxythymidine and 3'-fluoro-3'-deoxythymidine (positive controls .

引用

收藏

页码：1921 / 1925

页数：5

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