LONGITUDINAL ANALYSIS OF HEPATITIS-C VIRUS-INFECTION AND GENETIC DRIFT OF THE HYPERVARIABLE REGION

被引:28
作者
VANDOORN, LJ
QUINT, W
TSIQUAYE, K
VOERMANS, J
PAELINCK, D
KOS, T
MAERTENS, G
SCHELLEKENS, H
MURRAY, K
机构
[1] TNO,CTR PRIMATE,RIJSWIJK,NETHERLANDS
[2] SA INNOGENET NV,GHENT,BELGIUM
[3] UNIV LONDON LONDON SCH HYG & TROP MED,LONDON,ENGLAND
[4] UNIV EDINBURGH,INST CELL & MOLEC BIOL,EDINBURGH,SCOTLAND
关键词
D O I
10.1093/infdis/169.6.1226
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Hepatitis C virus (HCV) infections in a cohort of chimpanzees were studied retrospectively. All animals had been inoculated intravenously with materials derived from a single-source chimpanzee plasma implicated in non-A, non-B hepatitis, prepared by extensive ultracentrifugation. Anti-HCV and HCV RNA were monitored by the confirmatory line immunoassay and by an RNA-capture polymerase chain reaction method, respectively. In a chronically infected chimpanzee, HCV RNA was detectable after 32 days and throughout the acute phase, dropped transiently below detection level, and became detectable again. In 3 other chimpanzees with acute resolving infections, HCV RNA was detected 7-11 days after inoculation and became permanently undetectable after alanine aminotransferase normalization. Various anti-HCV profiles were detected among the chimpanzees. Analysis of the hypervariable region in E2/NS1 in 7 chimpanzees suggested genome stability on transmission, revealed different mutation frequencies during chronic infection, and suggested the importance of immune selection during chronic HCV infection.
引用
收藏
页码:1226 / 1235
页数:10
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