Phylogenetic, structural and functional analyses of the LacI-GalR family of bacterial transcription factors

被引：78

作者：

Nguyen, CC ^{[1
]}

Saier, MH ^{[1
]}

机构：

[1] UNIV CALIF SAN DIEGO, DEPT BIOL, LA JOLLA, CA 92093 USA

来源：

FEBS LETTERS | 1995年 / 377卷 / 02期

关键词：

transcription; regulation; DNA-binding protein; helix-turn-helix motif; evolution; phylogenetic tree;

D O I：

10.1016/0014-5793(95)01344-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Phylogenetic tree construction for 25 sequenced members of the LacI-GalR family (LGF) of transcription factors revealed that almost all branches are similar in length, radiating essentially from a single point, This observation suggests that most of these proteins arose by duplication events which occurred at a specific time in evolutionary history, and that further duplication events were rare, Analyses of the multiple alignment of the LGF proteins lead to suggestions regarding structure-function relationships and reveal that the helix-turn-helix DNA-binding motif of LGF proteins is similar in sequence to those of numerous non-homologous DNA-binding proteins.

引用

页码：98 / 102

页数：5