AN UNUSUAL CONDENSATION OF PYRIMIDINONES - SYNTHESIS OF BIPYRIMIDINONES AND BIPYRIMIDINYLMETHANE

被引：8

作者：

BOTTA, M ^{[1
]}

SALADINO, R ^{[1
]}

GAMBACORTA, A ^{[1
]}

NICOLETTI, R ^{[1
]}

机构：

[1] UNIV ROMA LA SAPIENZA,DIPARTMENTO CHIM,I-00185 ROME,ITALY

来源：

HETEROCYCLES | 1991年 / 32卷 / 08期

关键词：

D O I：

10.3987/COM-91-5751

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An unusual condensation of pyrimidinones (2), (3), and (12) in the presence of lithiated furan derivatives or LiHMDS leads to the formation of 7, 8 and 13. In the case of the self condensation of 3, a novel acyloin reaction is invoked to explain the formation of product (8) where the substrate acts as the catalyst in the reaction.

引用

页码：1537 / 1545

页数：9

共 15 条

[1] 6-ALKYL-2-METHOXY-4(3H)-PYRIMIDINONES AND 5,6-DIALKYL-2-METHOXY-4(3H)-PYRIMIDINONES IN THE TRANSFORMATIONS OF PYRIMIDINES - CONVERSION INTO 2-SUBSTITUTED "AMINO-CHLORO-PYRIMIDINE-DERIVATIVES AND 4-CHLORO-PYRIMIDINE-DERIVATIVES [J].

BOTTA, M ;

DEANGELIS, F ;

FINIZIA, G ;

GAMBACORTA, A ;

NICOLETTI, R .

SYNTHETIC COMMUNICATIONS, 1985, 15 (01) :27-34

[2] ANTIVIRAL AGENTS - SYNTHESIS OF FURYLPYRIMIDINONES AND EVALUATION OF THEIR CYTOSTATIC AND ANTIVIRAL ACTIVITY [J].

BOTTA, M ;

DEANGELIS, F ;

CORELLI, F ;

MENICHINCHERI, M ;

NICOLETTI, R ;

MARONGIU, ME ;

PANI, A ;

LACOLLA, P .

ARCHIV DER PHARMAZIE, 1991, 324 (04) :203-207

[3] PHOTOPRODUCT FREQUENCY IS NOT THE MAJOR DETERMINANT OF UV BASE SUBSTITUTION HOT-SPOTS OR COLD SPOTS IN HUMAN-CELLS [J].

BRASH, DE ;

SEETHARAM, S ;

KRAEMER, KH ;

SEIDMAN, MM ;

BREDBERG, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (11) :3782-3786

[4] ON THE MECHANISM OF THIAMINE ACTION .4. EVIDENCE FROM STUDIES ON MODEL SYSTEMS [J].

BRESLOW, R .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1958, 80 (14) :3719-3726

[5] UNFUSED HETEROBICYCLES AS AMPLIFIERS OF PHLEOMYCIN .2. SOME 2,4'-BIPYRIMIDINES, 4,5'-BIPYRIMIDINES AND 5,5'-BIPYRIMIDINES [J].

BROWN, DJ ;

COWDEN, WB ;

STREKOWSKI, L .

AUSTRALIAN JOURNAL OF CHEMISTRY, 1981, 34 (06) :1353-1359

[6]

BROWN DJ, 1985, HETEROCYCLIC, V16

[7]

ISMAIL MT, 1987, J ELECTROCHEM SOC IN, V36, P164

[8] A NEW CLASS OF BENZOIN CONDENSATION CATALYST, THE BI-(1,3-DIALKYLIMIDAZOLIDIN-2-YLIDENES) [J].

LAPPERT, MF ;

MASKELL, RK .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1982, (11) :580-581

[9] Reactions involving the addition of hydrogen cyanide to carbon compounds [J].

Lapworth, A .

JOURNAL OF THE CHEMICAL SOCIETY, 1903, 83 :995-1005

[10]

LEFEBVRE Y, 1972, TETRAHEDRON LETT, P133

← 1 2 →