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METABOLISM OF NEOSTIGMINE IN VITRO

被引：7
作者：
ROBERTS, JB
THOMAS, BH
WILSON, A
机构：
[1] Dept. of Pharmacology and General Therapeutics, University of Liverpool
来源：
BIOCHEMICAL PHARMACOLOGY | 1968年 / 17卷 / 01期
基金：
英国医学研究理事会;
关键词：
D O I：
10.1016/0006-2952(68)90151-2
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The metabolism of neostigmine by fractions of rat liver has been investigated using 14C neostigmine. It has been shown that the drug is metabolized to 3-hydroxy-phenyltrimethylammonium by the microsome fraction of rat liver and that the metabolism is completely inhibited by SKF 525-A. These results support the evidence from in vivo studies that the metabolism of neostigmine is inhibited by SKF 525-A. It is suggested that the clinical effects of neostigmine may be influenced by concurrent treatment with other drugs which are metabolized by the liver. © 1968.
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页码：9 / &
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