METABOLISM OF NEOSTIGMINE IN VITRO

被引：7

作者：

ROBERTS, JB

THOMAS, BH

WILSON, A

机构：

[1] Dept. of Pharmacology and General Therapeutics, University of Liverpool

来源：

BIOCHEMICAL PHARMACOLOGY | 1968年 / 17卷 / 01期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/0006-2952(68)90151-2

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The metabolism of neostigmine by fractions of rat liver has been investigated using 14C neostigmine. It has been shown that the drug is metabolized to 3-hydroxy-phenyltrimethylammonium by the microsome fraction of rat liver and that the metabolism is completely inhibited by SKF 525-A. These results support the evidence from in vivo studies that the metabolism of neostigmine is inhibited by SKF 525-A. It is suggested that the clinical effects of neostigmine may be influenced by concurrent treatment with other drugs which are metabolized by the liver. © 1968.

引用

页码：9 / &

共 13 条

[11] METABOLISM OF [14C]-NEOSTIGMINE IN RAT
ROBERTS, JB
THOMAS, BH
WILSON, A
[J]. BRITISH JOURNAL OF PHARMACOLOGY AND CHEMOTHERAPY, 1965, 25 (03): : 763 - &
[12] EXCRETION AND METABOLISM OF ORAL 14C-NEOSTIGMINE IN RAT
ROBERTS, JB
THOMAS, BH
WILSON, A
[J]. BIOCHEMICAL PHARMACOLOGY, 1966, 15 (01) : 71 - &
[13] INVESTIGATION OF METABOLISM OF NEOSTIGMINE IN PATIENTS WITH MYASTHENIA GRAVIS
SCOTT, CA
WILSON, A
NOWELL, PT
[J]. JOURNAL OF PHARMACY AND PHARMACOLOGY, 1962, 14 : T31 - &

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