T-CELL REGULATION OF THE ANTIBODY-RESPONSE TO BACTERIAL POLYSACCHARIDE ANTIGENS - AN EXAMINATION OF SOME GENERAL-CHARACTERISTICS AND THEIR IMPLICATIONS

被引：35

作者：

BAKER, PJ

机构：

[1] Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD

来源：

JOURNAL OF INFECTIOUS DISEASES | 1992年 / 165卷

关键词：

D O I：

10.1093/infdis/165-Supplement_1-S44

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The characteristics of thymus-derived (T) lymphocytes that regulate the magnitude of the antibody response to the capsular polysaccharide antigen of type III Streptococcus pneumoniae are considered within the context of a general homeostatic model for controlling the antibody response to microbial antigens of medical importance. Some experimental approaches are described in which the activities of such regulatory T cells are modulated to provide an increase in the development of host immunity, to improve the immunogenicity of poorly immunogenic antigens, or to eliminate the inhibitory effects of suppressor T cells.

引用

页码：S44 / S48

页数：5

共 41 条

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