SYNTHETIC STUDIES ON BRYOSTATINS, POTENT ANTINEOPLASTIC AGENTS - SYNTHESIS OF THE C-17-C-27 FRAGMENT OF C-20 OXYGENATED BRYOSTATINS

被引：24

作者：

OHMORI, K ^{[1
]}

NISHIYAMA, S ^{[1
]}

YAMAMURA, S ^{[1
]}

机构：

[1] KEIO UNIV,FAC SCI & TECHNOL,DEPT CHEM,YOKOHAMA,KANAGAWA 223,JAPAN

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 36期

关键词：

D O I：

10.1016/0040-4039(95)01310-E

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Synthetic process towards the bottom half portion of C-20 oxygenated series of bryostatins is described. The stereogenic center at C-20 position was constructed through a hydroxyl group-directed epoxidation by using mCPBA. It was found that silver (I) salt is an effective and mild reagent for regioselective ring cleavage of alpha-bromoepoxides into the corresponding alpha-hydroxyketones via oxonium ion intermediates.

引用

页码：6519 / 6522

页数：4

共 24 条

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