ESTIMATION OF EPIDERMAL GROWTH-FACTOR RECEPTOR IN 177 BREAST CANCERS - CORRELATION WITH PROGNOSTIC FACTORS

被引：35

作者：

BOLLA, M ^{[1
]}

CHEDIN, M ^{[1
]}

SOUVIGNET, C ^{[1
]}

MARRON, J ^{[1
]}

ARNOULD, C ^{[1
]}

CHAMBAZ, E ^{[1
]}

机构：

[1] CHU ALBERT MICHALLON,DEPT BIOCHEM,F-38043 GRENOBLE,FRANCE

来源：

BREAST CANCER RESEARCH AND TREATMENT | 1990年 / 16卷 / 02期

关键词：

breast cancer; EGF receptor; estrogen receptor; histologic grade; progesterone receptors;

D O I：

10.1007/BF01809293

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Steroid receptors (ER, PR) and EGF-receptor were determined on 177 loco-regional primary breast cancers. Binding assay for EGF receptor was performed using a single saturating concentration of125I-EGF incubated with membranes in the presence or absence of unlabeled EGF. With threshold values of 5 fmol/mg and 10 fmol/mg for EGF-R and steroid receptors respectively, we noted an inverse relationship between the expression of EGF-R, and ER and PR. EGF-R expression is decreased with tumor differentiation. © 1990 Kluwer Academic Publishers.

引用

页码：97 / 102

页数：6

共 23 条

[1] EPIDERMAL GROWTH-FACTOR RECEPTOR IN HUMAN-BREAST CANCER - CORRELATION WITH STEROID-HORMONE RECEPTORS AND AXILLARY LYMPH-NODE INVOLVEMENT [J].

BATTAGLIA, F ;

SCAMBIA, G ;

ROSSI, S ;

PANICI, PB ;

BELLANTONE, R ;

POLIZZI, G ;

QUERZOLI, P ;

NEGRINI, R ;

IACOBELLI, S ;

CRUCITTI, F ;

MANCUSO, S .

EUROPEAN JOURNAL OF CANCER & CLINICAL ONCOLOGY, 1988, 24 (11) :1685-1690

[2]

BOLLA M, 1987, B CANCER, V74, P623

[3] THE INFLUENCE OF HORMONE RECEPTORS AND HORMONAL ADJUVANT THERAPY ON DISEASE-FREE SURVIVAL IN BREAST-CANCER - A MULTIFACTORIAL ANALYSIS [J].

CALDAROLA, L ;

VOLTERRANI, P ;

CALDAROLA, B ;

LAI, M ;

JAYME, A ;

GAGLIA, P .

EUROPEAN JOURNAL OF CANCER & CLINICAL ONCOLOGY, 1986, 22 (02) :151-155

[4] SIMULTANEOUS ESTIMATION OF EPIDERMAL GROWTH-FACTOR RECEPTORS AND STEROID-RECEPTORS IN A SERIES OF 136 RESECTABLE PRIMARY BREAST-TUMORS [J].

CAPPELLETTI, V ;

BRIVIO, M ;

MIODINI, P ;

GRANATA, G ;

CORADINI, D ;

DIFRONZO, G .

TUMOR BIOLOGY, 1988, 9 (04) :200-211

[5] SCATCHARD PLOTS - COMMON ERRORS IN CORRECTION AND INTERPRETATION [J].

CHAMNESS, GC ;

MCGUIRE, WL .

STEROIDS, 1975, 26 (04) :538-542

[6]

CHEVALLIER B, 1988, B CANCER, V75, P23

[7] EPIDERMAL GROWTH-FACTOR RECEPTOR IN HUMAN-BREAST CANCERS - CORRELATION WITH ESTROGEN AND PROGESTERONE RECEPTORS [J].

DELARUE, JC ;

FRIEDMAN, S ;

MOURIESSE, H ;

MAYLEVIN, F ;

SANCHOGARNIER, H ;

CONTESSO, G .

BREAST CANCER RESEARCH AND TREATMENT, 1988, 11 (02) :173-178

[8]

FITZPATRICK SL, 1984, CANCER RES, V44, P3448

[9]

FITZPATRICK SL, 1984, CANCER RES, V44, P3442

[10]

HARRIS AL, 1987, HORMONAL MANIPULATIO, P415

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