ESTIMATION OF EPIDERMAL GROWTH-FACTOR RECEPTOR IN 177 BREAST CANCERS - CORRELATION WITH PROGNOSTIC FACTORS

被引：35

作者：

BOLLA, M ^{[1
]}

CHEDIN, M ^{[1
]}

SOUVIGNET, C ^{[1
]}

MARRON, J ^{[1
]}

ARNOULD, C ^{[1
]}

CHAMBAZ, E ^{[1
]}

机构：

[1] CHU ALBERT MICHALLON,DEPT BIOCHEM,F-38043 GRENOBLE,FRANCE

来源：

BREAST CANCER RESEARCH AND TREATMENT | 1990年 / 16卷 / 02期

关键词：

breast cancer; EGF receptor; estrogen receptor; histologic grade; progesterone receptors;

D O I：

10.1007/BF01809293

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Steroid receptors (ER, PR) and EGF-receptor were determined on 177 loco-regional primary breast cancers. Binding assay for EGF receptor was performed using a single saturating concentration of125I-EGF incubated with membranes in the presence or absence of unlabeled EGF. With threshold values of 5 fmol/mg and 10 fmol/mg for EGF-R and steroid receptors respectively, we noted an inverse relationship between the expression of EGF-R, and ER and PR. EGF-R expression is decreased with tumor differentiation. © 1990 Kluwer Academic Publishers.

引用

页码：97 / 102

页数：6