NOVEL QUATERNARY AMMONIUM SALT-CONTAINING POLYAMINES FROM THE AGELENOPSIS-APERTA FUNNEL-WEB SPIDER

被引：43

作者：

JASYS, VJ ^{[1
]}

KELBAUGH, PR ^{[1
]}

NASON, DM ^{[1
]}

PHILLIPS, D ^{[1
]}

ROSNACK, KJ ^{[1
]}

FORMAN, JT ^{[1
]}

SACCOMANO, NA ^{[1
]}

STROH, JG ^{[1
]}

VOLKMANN, RA ^{[1
]}

机构：

[1] PFIZER INC,DIV CENT RES,GROTON,CT 06340

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1992年 / 57卷 / 06期

关键词：

D O I：

10.1021/jo00032a039

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two novel hydroxylamine-containing acylpolyamines, Agel 489a and Agel 505a, each bearing a terminal quaternary ammonium salt, were isolated from the venom of Agelenopsis aperta, a funnel-web spider found throughout the western United States. Published structures for these compounds were not consistent with our spectral data. On the basis of fast-atom bombardment (FAB) mass spectrometry and H-1 and C-13 NMR spectra, novel structures for Agel 489a and 505a are proposed. These structural assignments are confirmed by the total synthesis of Agel 489a.

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页码：1814 / 1820

页数：7

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