ORGANIC DUST TOXIC SYNDROME - AN ACUTE FEBRILE REACTION TO ORGANIC DUST EXPOSURE DISTINCT FROM HYPERSENSITIVITY PNEUMONITIS

被引:68
作者
VONESSEN, S [1 ]
ROBBINS, RA [1 ]
THOMPSON, AB [1 ]
RENNARD, SI [1 ]
机构
[1] VET ADM MED CTR,OMAHA,NE 68105
来源
JOURNAL OF TOXICOLOGY-CLINICAL TOXICOLOGY | 1990年 / 28卷 / 04期
关键词
D O I
10.3109/15563659009038584
中图分类号
R99 [毒物学(毒理学)];
学科分类号
100405 ;
摘要
Organic dust toxic syndrome is a term recently coined to describe a noninfectious, febrile illness associated with chills, malaise, myalgia, a dry cough, dyspnea, headache and nausea which occurs after heavy organic dust exposure. Organic dust toxic syndrome shares many clinical features with acute farmer's lung and other forms of hypersensitivity pneumonitis, including the presence of increased numbers of neutrophils in bronchoalveolar lavage. However, organic dust toxic syndrome differs from acute hypersensitivity pneumonitis in several respects: the chest X-ray does not show infiltrates, severe hypoxemia does not occur, prior sensitization to antigens in the organic dust is not required and there are no known sequelae of physiological significance, such as the recurrent attacks and the pulmonary fibrosis which may be seen with chronic hypersensitivity pneumonitis. Organic dust toxic syndrome is thought to be much more common than farmer's lung. It is important for clinical and investigational purposes that organic dust toxic syndrome be distinguished from acute farmer's lung.
引用
收藏
页码:389 / 420
页数:32
相关论文
共 78 条
[41]   EXPOSURE TO MICROORGANISMS, FEBRILE AND AIRWAY-OBSTRUCTIVE SYMPTOMS, IMMUNE STATUS AND LUNG-FUNCTION OF SWEDISH FARMERS [J].
MALMBERG, P ;
RASKANDERSEN, A ;
PALMGREN, U ;
HOGLUND, S ;
KOLMODINHEDMAN, B ;
STALENHEIM, G .
SCANDINAVIAN JOURNAL OF WORK ENVIRONMENT & HEALTH, 1985, 11 (04) :287-293
[42]  
MARX JJ, 1975, J ALLERGY CLIN IMMUN, V55, P70
[43]   ORGANIC DUST TOXICITY (PULMONARY MYCOTOXICOSIS) ASSOCIATED WITH SILO UNLOADING [J].
MAY, JJ ;
STALLONES, L ;
DARROW, D ;
PRATT, DS .
THORAX, 1986, 41 (12) :919-923
[44]   A STUDY OF SILO UNLOADING - THE WORK-ENVIRONMENT AND ITS PHYSIOLOGICAL-EFFECTS [J].
MAY, JJ ;
PRATT, DS ;
STALLONES, L ;
MOREY, PR ;
OLENCHOCK, SA ;
DEEP, IW ;
BENNETT, GA .
AMERICAN JOURNAL OF INDUSTRIAL MEDICINE, 1986, 10 (03) :318-318
[45]  
MAY JJ, 1990, AM J IND MED, V17, P111
[46]   IMMUNOLOGICAL EVENTS IN PIGEON BREEDERS DISEASE [J].
MOORE, VL ;
FINK, JN ;
BARBORIAK, JJ ;
RUFF, LL ;
SCHLUETER, DP .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1974, 53 (06) :319-328
[47]  
MUELLER-WENING D, 1989, Chest, V95, P100
[48]  
OLENCHOCK SA, 1980, ANN ALLERGY, V44, P23
[49]   ROLE OF PRECIPITINS AND COMPLEMENT ACTIVATION IN ETIOLOGY OF ALLERGIC LUNG-DISEASE [J].
OLENCHOCK, SA ;
BURRELL, R .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1976, 58 (01) :76-88
[50]  
PEPYS J, 1962, THORAX, V17, P336