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HUMAN GLUTATHIONE S-TRANSFERASES - RADIOIMMUNOASSAY STUDIES ON THE EXPRESSION OF ALPHA-CLASS, MU-CLASS AND PI-CLASS ISOENZYMES IN DEVELOPING LUNG AND KIDNEY

被引：36
作者：
BECKETT, GJ
HOWIE, AF
HUME, R
MATHAROO, B
HILEY, C
JONES, P
STRANGE, RC
机构：
[1] UNIV EDINBURGH,ROYAL EDINBURGH INFIRM,DEPT CLIN CHEM,EDINBURGH EH10 5HF,MIDLOTHIAN,SCOTLAND
[2] UNIV EDINBURGH,ROYAL EDINBURGH INFIRM,DEPT CHILD LIFE & HLTH,EDINBURGH EH10 5HF,MIDLOTHIAN,SCOTLAND
[3] UNIV KEELE,SCH POSTGRAD MED & BIOL SCI,CLIN BIOCHEM RES LAB,KEELE ST5 5BG,STAFFS,ENGLAND
[4] UNIV KEELE,DEPT MATH,KEELE ST5 5BG,STAFFS,ENGLAND
来源：
BIOCHIMICA ET BIOPHYSICA ACTA | 1990年 / 1036卷 / 03期
关键词：
GLUTATHIONE S-TRANSFERASE; DEVELOPMENT; (HUMAN LUNG); (HUMAN KIDNEY);
D O I：
10.1016/0304-4165(90)90031-Q
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The developmental expression of the alpha-, mu- and pi-class glutathione S-transferases has been defined in human lung and kidney using radioimmunoassay, immunohistochemistry and column chromatography. Expression of alpha-class enzymes increased significantly after about 40 weeks gestation in kidney but not lung, while expression of mu isoenzymes was continuous throughout development in both tissues. Expression of the pi isoenzyme fell during in utero ontogeny in lung, the pattern of down-regulation being similar to that previously observed in liver. There was no change in the expression of this isoenzyme in kidney. Comparison of the expression of the glutathione S-transferases in developing lung, kidney and liver shows some common patterns of expression suggesting these genes are under similar regulatory control.
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页码：176 / 182
页数：7
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