CALCIUM-REGULATED PHOSPHORYLATION WITHIN THE LEUCINE ZIPPER OF C/EBP-BETA

被引：357

作者：

WEGNER, M

CAO, ZD

ROSENFELD, MG

机构：

[1] UNIV CALIF SAN DIEGO,EUKARYOT REGULATORY BIOL PROGRAM,CELLULAR & MOLEC MED BLDG,LA JOLLA,CA 92093

[2] CARNEGIE INST WASHINGTON,DEPT EMBRYOL,HOWARD HUGHES RES LABS,BALTIMORE,MD 21210

[3] UNIV CALIF SAN DIEGO,HOWARD HUGHES MED INST,LA JOLLA,CA 92093

来源：

SCIENCE | 1992年 / 256卷 / 5055期

关键词：

D O I：

10.1126/science.256.5055.370

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Alterations in intracellular calcium levels activate several signal transduction pathways resulting in distinct patterns of gene expression. Here, a pathway for calcium-mediated signals is demonstrated that involves C/EBP-beta, a member of the bZip family of transcription factors. In pituitary cells C/EBP-beta was phosphorylated in response to increased intracellular calcium concentrations as a consequence of the activation of a calcium-calmodulin-dependent protein kinase. Phosphorylation of serine at position 276 within the leucine zipper of C/EBP-beta appeared to confer calcium-regulated transcriptional stimulation of a promoter that contained binding sites for C/EBP-beta.

引用

页码：370 / 373

页数：4

共 44 条

[1] A NUCLEAR FACTOR FOR IL-6 EXPRESSION (NF-IL6) IS A MEMBER OF A C/EBP FAMILY
AKIRA, S
ISSHIKI, H
SUGITA, T
TANABE, O
KINOSHITA, S
NISHIO, Y
NAKAJIMA, T
HIRANO, T
KISHIMOTO, T
[J]. EMBO JOURNAL, 1990, 9 (06) : 1897 - 1906
[2] ONCOGENE JUN ENCODES A SEQUENCE-SPECIFIC TRANS-ACTIVATOR SIMILAR TO AP-1
ANGEL, P
ALLEGRETTO, EA
OKINO, ST
HATTORI, K
BOYLE, WJ
HUNTER, T
KARIN, M
[J]. NATURE, 1988, 332 (6160) : 166 - 171
[3] DEDUCED PRIMARY STRUCTURE OF THE BETA-SUBUNIT OF BRAIN TYPE-II CA-2+/CALMODULIN-DEPENDENT PROTEIN-KINASE DETERMINED BY MOLECULAR-CLONING
BENNETT, MK
KENNEDY, MB
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (07) : 1794 - 1798
[4] TISSUE-SPECIFIC EXPRESSION, DEVELOPMENTAL REGULATION, AND GENETIC-MAPPING OF THE GENE ENCODING CCAAT ENHANCER BINDING-PROTEIN
BIRKENMEIER, EH
GWYNN, B
HOWARD, S
JERRY, J
GORDON, JI
LANDSCHULZ, WH
MCKNIGHT, SL
[J]. GENES & DEVELOPMENT, 1989, 3 (08) : 1146 - 1156
[5] HUMAN PROTOONCOGENE C-JUN ENCODES A DNA-BINDING PROTEIN WITH STRUCTURAL AND FUNCTIONAL-PROPERTIES OF TRANSCRIPTION FACTOR AP-1
BOHMANN, D
BOS, TJ
ADMON, A
NISHIMURA, T
VOGT, PK
TJIAN, R
[J]. SCIENCE, 1987, 238 (4832) : 1386 - 1392
[6] CONSERVED AND VARIABLE REGIONS IN THE SUBUNITS OF BRAIN TYPE-II CA-2+ CALMODULIN-DEPENDENT PROTEIN-KINASE
BULLEIT, RF
BENNETT, MK
MOLLOY, SS
HURLEY, JB
KENNEDY, MB
[J]. NEURON, 1988, 1 (01) : 63 - 72
[7] BURGIN KE, 1990, J NEUROSCI, V10, P1788
[8] REGULATED EXPRESSION OF 3 C/EBP ISOFORMS DURING ADIPOSE CONVERSION OF 3T3-L1 CELLS
CAO, ZD
UMEK, RM
MCKNIGHT, SL
[J]. GENES & DEVELOPMENT, 1991, 5 (09) : 1538 - 1552
[9] ENDOCYTOSIS OF THE CLASS-I MAJOR HISTOCOMPATIBILITY ANTIGEN VIA A PHORBOL-MYRISTATE ACETATE-INDUCIBLE PATHWAY IS A CELL-SPECIFIC PHENOMENON AND REQUIRES THE CYTOPLASMIC DOMAIN
CAPPS, GG
VANKAMPEN, M
WARD, CL
ZUNIGA, MC
[J]. JOURNAL OF CELL BIOLOGY, 1989, 108 (04) : 1317 - 1329
[10] MOLECULAR-CLONING OF A TRANSCRIPTION FACTOR, AGP EBP, THAT BELONGS TO MEMBERS OF THE C/EBP FAMILY
CHANG, CJ
CHEN, TT
LEI, HY
CHEN, DS
LEE, SC
[J]. MOLECULAR AND CELLULAR BIOLOGY, 1990, 10 (12) : 6642 - 6653

← 1 2 3 4 5 →