A SINGLE-STRANDED-DNA BINDING-PROTEIN WHICH INTERACTS WITH SEQUENCES WITHIN THE BOVINE PREPROTACHYKININ PROMOTER - REGULATION BY NERVE GROWTH-FACTOR

被引：14

作者：

GILCHRIST, CA ^{[1
]}

MORRISON, CF ^{[1
]}

HARMAR, AJ ^{[1
]}

机构：

[1] ROYAL EDINBURGH & ASSOC HOSP,MRC,BRAIN METAB UNIT,EDINBURGH,SCOTLAND

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1992年 / 187卷 / 03期

关键词：

D O I：

10.1016/0006-291X(92)90457-V

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The production of substance P (SP) and the mRNA encoding its precursor preprotachykinin (PPT) is regulated by nerve growth factor (NGF) in dorsal root ganglion neurons (1). We have shown previously that two regions of the bovine PPT promoter are capable of mediating the induction by NGF of the downstream structural gene in transfected PC12 cells (2). Both regions contained a sequence element, similar to a known transcription factor binding site, which is present in several other NGF-regulated genes. We show here that PC12 cells contain a single-stranded DNA binding protein (SSBP-PC12) which can interact specifically with this site. Binding activity was increased by NGF treatment of PC12 cells. © 1992.

引用

页码：1395 / 1400

页数：6

共 20 条

[1] INDUCTION OF AMYLOID PRECURSOR PROTEIN MESSENGER-RNA AFTER HEAT-SHOCK IN CULTURED HUMAN LYMPHOBLASTOID-CELLS [J].

ABE, K ;

STGEORGEHYSLOP, PH ;

TANZI, RE ;

KOGURE, K .

NEUROSCIENCE LETTERS, 1991, 125 (02) :169-171

[2] ACCURATE TRANSCRIPTION INITIATION BY RNA POLYMERASE-II IN A SOLUBLE EXTRACT FROM ISOLATED MAMMALIAN NUCLEI [J].

DIGNAM, JD ;

LEBOVITZ, RM ;

ROEDER, RG .

NUCLEIC ACIDS RESEARCH, 1983, 11 (05) :1475-1489

[3] NEUROCHEMICAL CHARACTERISTICS OF A NOVEL DORSAL-ROOT GANGLION X NEUROBLASTOMA HYBRID CELL-LINE, F-11 [J].

FRANCEL, PC ;

HARRIS, K ;

SMITH, M ;

FISHMAN, MC ;

DAWSON, G ;

MILLER, RJ .

JOURNAL OF NEUROCHEMISTRY, 1987, 48 (05) :1624-1631

[4] IDENTIFICATION OF NERVE GROWTH FACTOR-RESPONSIVE SEQUENCES WITHIN THE 5' REGION OF THE BOVINE PREPROTACHYKININ GENE [J].

GILCHRIST, CA ;

MORRISON, CF ;

CHAPMAN, KE ;

HARMAR, AJ .

DNA AND CELL BIOLOGY, 1991, 10 (10) :743-749

[5]

GINTY DD, 1991, J BIOL CHEM, V266, P15325

[6] ESTABLISHMENT OF A NORADRENERGIC CLONAL LINE OF RAT ADRENAL PHEOCHROMOCYTOMA CELLS WHICH RESPOND TO NERVE GROWTH-FACTOR [J].

GREENE, LA ;

TISCHLER, AS .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1976, 73 (07) :2424-2428

[7] IDENTIFICATION AND PURIFICATION OF A PROTEIN THAT BINDS THE YEAST ARS CONSENSUS SEQUENCE [J].

HOFMANN, JFX ;

GASSER, SM .

CELL, 1991, 64 (05) :951-960

[8]

KAGEYAMA R, 1991, J BIOL CHEM, V266, P15525

[9] HEAT-INDUCIBLE HUMAN FACTOR THAT BINDS TO A HUMAN HSP70 PROMOTER [J].

KINGSTON, RE ;

SCHUETZ, TJ ;

LARIN, Z .

MOLECULAR AND CELLULAR BIOLOGY, 1987, 7 (04) :1530-1534

[10] NERVE GROWTH-FACTOR REGULATES EXPRESSION OF NEUROPEPTIDE GENES IN ADULT SENSORY NEURONS [J].

LINDSAY, RM ;

HARMAR, AJ .

NATURE, 1989, 337 (6205) :362-364

← 1 2 →