The Role of Fibroblast Growth Factor 21 (FGF21) on Energy Balance, Glucose and Lipid Metabolism

被引：54

作者：

Cuevas-Ramos, Daniel ^{[1
]}

Almeda-Valdes, Paloma ^{[1
]}

Aguilar-Salinas, Carlos A. ^{[1
]}

Cuevas-Ramos, Gabriel ^{[2
]}

Cuevas-Sosa, Andres A. ^{[3
]}

Gomez-Perez, Francisco J. ^{[1
]}

机构：

[1] Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Endocrinol & Metab, Vasco Quiroga 15,Secc XVI, Mexico City 14000, DF, Mexico

[2] Ecole Natl Veterinaire Toulouse, Toulouse, France

[3] Centro Invest Psicoanal & Psicoterapia, Mexico City, DF, Mexico

来源：

CURRENT DIABETES REVIEWS | 2009年 / 5卷 / 04期

关键词：

Fibroblast growth factor 21; Glucose; Energy balance; Insulin; Metabolic syndrome; Type 2 diabetes mellitus;

D O I：

10.2174/157339909789804396

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

FGF21 is a novel member of the FGFs family, is mainly expressed in liver and it functions as a potent activator of glucose uptake on adipocytes. When over expressed in transgenic mice, it protects animals from diet-induced obesity and its administration to diabetic rodents and monkeys lowers blood glucose and triglyceride levels. Recently, increased levels of FGF21 have been identified as an independent risk factor related with metabolic syndrome. A review of the relevant roles of FGF21 in metabolism is presented here.

引用

页码：216 / 220

页数：5

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