THE MATRIX PROTEINS OF NEUROVIRULENT SUBACUTE SCLEROSING PANENCEPHALITIS VIRUS AND ITS ACUTE MEASLES-VIRUS PROGENITOR ARE FUNCTIONALLY DIFFERENT

被引:42
作者
HIRANO, A
WANG, AH
GOMBART, AF
WONG, TC
机构
[1] Department of Microbiology, Washington Univ. School of Medicine, Seattle
关键词
VIRUS MATURATION; PERSISTENT INFECTION;
D O I
10.1073/pnas.89.18.8745
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Persistence of measles virus in the brains of patients with subacute sclerosing panencephalitis (SSPE) is accompanied by changes in the viral matrix (M) protein. To understand the significance of these changes, cell culture and cell-free assays were developed to compare the functions of the M proteins of an SSPE virus Biken strain and its acute measles virus progenitor Nagahata strain. The Nagahata viral M protein is associated with the intracellular viral nucleocapsids and the plasma membrane, whereas the Biken viral M protein is localized mainly in the cytosol. The lack of M protein in the Biken viral nucleocapsids is due to a failure of the Biken M protein to bind to the viral nucleocapsids. The Biken M protein also fails to bind to the Nagahata viral nucleocapsids. Conversely, the Nagahata M protein can bind to the Biken viral nucleocapsids, although this association is not as stable at physiological salt concentration. These results offer concrete evidence that the M protein of an SSPE virus is functionally different from that of its progenitor acute measles virus.
引用
收藏
页码:8745 / 8749
页数:5
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