Adhesion or anti-adhesion in cancer: What matters more?

被引:37
作者
Jothy, S
Munro, SB
LeDuy, L
McClure, D
Blaschuk, OW
机构
[1] MCGILL UNIV,DEPT ONCOL,CTR CANC,MONTREAL,PQ H3A 2B4,CANADA
[2] MCGILL UNIV,DEPT SURG,DIV UROL,MONTREAL,PQ H3A 2T5,CANADA
[3] ROYAL VICTORIA HOSP,MONTREAL,PQ H3A 1A1,CANADA
关键词
cell adhesion; CEA; CD44; cadherin; cancer; colon carcinoma;
D O I
10.1007/BF00690604
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The regulation of adhesion processes between normal epithelial cells is an essential condition for the maintenance of appropriate tissular architecture and differentiation. Quantitative and qualitative alterations in these homotypic adhesions occur during the transformation of normal into malignant epithelium. How these complex alterations in various homotypic adhesions modify the ability of tumor cells to detach from the original neoplastic site, to grow and move as single or clumped cells, and to invade the stroma are current issues in tumor biology. This review contrasts tumor cell adhesion mediated by E-cadherin which is consistently decreased in carcinomas, with adhesion mediated by CD44 and CEA which are increased in the same tumors. A model proposing to resolve the apparent paradox of simultaneous adhesion and anti-adhesion mediated by the same protein is proposed.
引用
收藏
页码:363 / 376
页数:14
相关论文
共 77 条
[51]   PREVENTION OF TUMOR-METASTASIS FORMATION BY ANTIVARIANT CD44 [J].
SEITER, S ;
ARCH, R ;
REBER, S ;
KOMITOWSKI, D ;
HOFMANN, M ;
PONTA, H ;
HERRLICH, P ;
MATZKU, S ;
ZOLLER, M .
JOURNAL OF EXPERIMENTAL MEDICINE, 1993, 177 (02) :443-455
[52]   STRUCTURAL BASIS OF CELL-CELL ADHESION BY CADHERINS [J].
SHAPIRO, L ;
FANNON, AM ;
KWONG, PD ;
THOMPSON, A ;
LEHMANN, MS ;
GRUBEL, G ;
LEGRAND, JF ;
ALSNIELSEN, J ;
COLMAN, DR ;
HENDRICKSON, WA .
NATURE, 1995, 374 (6520) :327-337
[53]  
SHIMOYAMA Y, 1989, CANCER RES, V49, P2128
[54]  
SHIMOYAMA Y, 1991, CANCER RES, V51, P2185
[55]  
SHIMOYAMA Y, 1992, CANCER RES, V52, P5770
[56]  
SHIOZAKI H, 1991, AM J PATHOL, V139, P17
[57]   PROTEIN-G-GOLD IMMUNOELECTRON MICROSCOPY OF COLON-CARCINOMA - THE EFFECT OF TUMOR DIFFERENTIATION ON CARCINOEMBRYONIC ANTIGEN IMMUNOSTAINING [J].
SHIROTA, K ;
MINASSIAN, H ;
JOTHY, S .
EXPERIMENTAL AND MOLECULAR PATHOLOGY, 1988, 49 (03) :305-315
[58]  
SOMMERS CL, 1991, CELL GROWTH DIFFER, V2, P365
[59]   A LYMPHOCYTE MOLECULE IMPLICATED IN LYMPH-NODE HOMING IS A MEMBER OF THE CARTILAGE LINK PROTEIN FAMILY [J].
STAMENKOVIC, I ;
AMIOT, M ;
PESANDO, JM ;
SEED, B .
CELL, 1989, 56 (06) :1057-1062
[60]   THE HEMATOPOIETIC AND EPITHELIAL FORMS OF CD44 ARE DISTINCT POLYPEPTIDES WITH DIFFERENT ADHESION POTENTIALS FOR HYALURONATE-BEARING CELLS [J].
STAMENKOVIC, I ;
ARUFFO, A ;
AMIOT, M ;
SEED, B .
EMBO JOURNAL, 1991, 10 (02) :343-348