REACTIVE OXYGEN SPECIES ARE INVOLVED IN THE ACTIVATION OF CELLULAR PHOSPHOLIPASE-A2

被引:86
作者
GOLDMAN, R
FERBER, E
ZORT, U
机构
[1] WEIZMANN INST SCI,DEPT HORMONE RES,IL-76100 REHOVOT,ISRAEL
[2] MAX PLANCK INST IMMUNBIOL,W-7800 FREIBURG,GERMANY
关键词
PHOSPHOLIPASE-A2; NADPH OXIDASE; REACTIVE OXYGEN SPECIES; DIPHENYLENE IODONIUM; VANADATE; TYROSINE PROTEIN PHOSPHATASE;
D O I
10.1016/0014-5793(92)81092-Z
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Vanadate (V) potentiated (4- to 10-fold) the activation of cellular phospholipase A2 (PLA2) induced by H2O2 (H), a phorbol ester (T), a Ca2+-ionophore (A) and opsonized zymosan in macrophages. V+H induced in intact cells the activation and translocation of PLA2 and protein kinase C (PKC) to the plasma membrane. V+H and V+T+A induced strong chemiluminescence (CL) which was abrogated by a specific NADPH oxidase inhibitor diphenylene iodonium (DPI). DPI markedly suppressed the stimulation of PLA2 by V+T+A and V+OZ. The results suggest that the formation of endogenous reactive oxygen species (ROS) is important for PLA2 activation.
引用
收藏
页码:190 / 192
页数:3
相关论文
共 22 条
[11]   HUMAN FAT-CELLS POSSESS A PLASMA-MEMBRANE BOUND H2O2-GENERATING SYSTEM THAT IS ACTIVATED BY INSULIN VIA A MECHANISM BYPASSING THE RECEPTOR KINASE [J].
KRIEGERBRAUER, HI ;
KATHER, H .
JOURNAL OF CLINICAL INVESTIGATION, 1992, 89 (03) :1006-1013
[12]   THE ROLES OF O-2-, HO., AND SECONDARILY DERIVED RADICALS IN OXIDATION REACTIONS CATALYZED BY VANADIUM SALTS [J].
LIOCHEV, SI ;
FRIDOVICH, I .
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1991, 291 (02) :379-382
[13]  
NACCACHE PH, 1990, BLOOD, V76, P2098
[14]   TRANSLOCATION OF PHOSPHOLIPASE-A2 FROM CYTOSOL TO MEMBRANES INDUCED BY 1-OLEOYL-2-ACETYL-GLYCEROL IN SERUM-FREE CULTURED MACROPHAGES [J].
SCHONHARDT, T ;
FERBER, E .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1987, 149 (02) :769-775
[15]   REACTIVE OXYGEN INTERMEDIATES AS APPARENTLY WIDELY USED MESSENGERS IN THE ACTIVATION OF THE NF-KAPPA-B TRANSCRIPTION FACTOR AND HIV-1 [J].
SCHRECK, R ;
RIEBER, P ;
BAEUERLE, PA .
EMBO JOURNAL, 1991, 10 (08) :2247-2258
[16]   DIFFERENTIAL DEPENDENCE ON PROTEIN-KINASE-C OF ARACHIDONIC-ACID METABOLISM STIMULATED BY HYDROGEN-PEROXIDE AND BY ZYMOSAN IN THE ALVEOLAR MACROPHAGE [J].
SPORN, PHS ;
MARSHALL, TM ;
PETERSGOLDEN, M .
BIOCHIMICA ET BIOPHYSICA ACTA, 1990, 1047 (02) :187-191
[17]   MECHANISM OF VANADATE-INDUCED ACTIVATION OF TYROSINE PHOSPHORYLATION AND OF THE RESPIRATORY BURST IN HL60 CELLS - ROLE OF REDUCED OXYGEN METABOLITES [J].
TRUDEL, S ;
PAQUET, MR ;
GRINSTEIN, S .
BIOCHEMICAL JOURNAL, 1991, 276 :611-619
[18]   THE EFFECT OF PUTATIVE PROTEIN KINASE-C INHIBITORS, K252A AND STAUROSPORINE, ON THE HUMAN NEUTROPHIL RESPIRATORY BURST ACTIVATED BY BOTH RECEPTOR STIMULATION AND POSTRECEPTOR MECHANISMS [J].
TWOMEY, B ;
MUID, RE ;
DALE, MM .
BRITISH JOURNAL OF PHARMACOLOGY, 1990, 100 (04) :819-825
[19]   AN 100-KDA ARACHIDONATE-MOBILIZING PHOSPHOLIPASE-A2 IN MOUSE SPLEEN AND THE MACROPHAGE CELL-LINE J774 - PURIFICATION, SUBSTRATE INTERACTION AND PHOSPHORYLATION BY PROTEIN-KINASE-C [J].
WIJKANDER, J ;
SUNDLER, R .
EUROPEAN JOURNAL OF BIOCHEMISTRY, 1991, 202 (03) :873-880
[20]   A ROLE FOR PROTEIN-KINASE C-MEDIATED PHOSPHORYLATION IN THE MOBILIZATION OF ARACHIDONIC-ACID IN MOUSE MACROPHAGES [J].
WIJKANDER, J ;
SUNDLER, R .
BIOCHIMICA ET BIOPHYSICA ACTA, 1989, 1010 (01) :78-87