INSULINIC ACTIONS OF VANADATE IN DIABETIC RATS

被引：55

作者：

SEKAR, N

KANTHASAMY, A

WILLIAM, S

SUBRAMANIAN, S

GOVINDASAMY, S

机构：

[1] Department of Biochemistry, University of Madras, Madras, 600 025, Guindy Campus

来源：

PHARMACOLOGICAL RESEARCH | 1990年 / 22卷 / 02期

关键词：

carbohydrate metabolism; insulinic actions; vanadate;

D O I：

10.1016/1043-6618(90)90717-R

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Oral administration of sodium orthovanadate (0·3 mg/dl) normalizes blood glucose and reduces glycosylated HbA1 levels in streptozotocin induced diabetic rats without any increase in the serum insulin levels. However, diabetic condition reappears after withdrawal of vanadate. Assays of carbohydrate metabolizing enzymes clearly indicate that vanadate activates the glycolysis, glycogenesis and depresses the glycogenolysis and gluconeogenesis in diabetic rats. These results demonstrate that vanadate substitutes insulin action in chronic experimental diabetics. © 1990 The Italian Pharmacological Society.

引用

页码：207 / 217

页数：11

共 31 条

[11]

GIL J, 1988, J BIOL CHEM, V263, P1868

[12] THE INSULIN-LIKE EFFECT OF SODIUM VANADATE ON ADIPOCYTE GLUCOSE-TRANSPORT IS MEDIATED AT A POST-INSULIN-RECEPTOR LEVEL [J].