SYNTHESIS AND ANTIHYPERTENSIVE ACTIVITY OF 4'-SUBSTITUTED SPIRO[4H-3,1-BENZOXAZINE-4,4'-PIPERIDIN]-2(1H)-ONES

被引:98
作者
CLARK, RD [1 ]
CAROON, JM [1 ]
KLUGE, AF [1 ]
REPKE, DB [1 ]
ROSZKOWSKI, AP [1 ]
STROSBERG, AM [1 ]
BAKER, S [1 ]
BITTER, SM [1 ]
OKADA, MD [1 ]
机构
[1] SYNTEX RES CORP,INST PHARMACOL & METAB,PALO ALTO,CA 94304
关键词
D O I
10.1021/jm00359a007
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
引用
收藏
页码:657 / 661
页数:5
相关论文
共 14 条
[1]  
BECKETT PJ, 1981, BRIT J PHARMACOL, V74, pP190
[2]   SYNTHESIS AND ANTIHYPERTENSIVE ACTIVITY OF A SERIES OF 8-SUBSTITUTED 1-OXA-3,8-DIAZASPIRO[4.5]DECAN-2-ONES [J].
CAROON, JM ;
CLARK, RD ;
KLUGE, AF ;
NELSON, JT ;
STROSBERG, AM ;
UNGER, SH ;
MICHEL, AD ;
WHITING, RL .
JOURNAL OF MEDICINAL CHEMISTRY, 1981, 24 (11) :1320-1328
[3]  
CLARK RD, J MED CHEM
[4]   CENTRALLY ACTING ANTIHYPERTENSIVE AGENT (R28935) NOT MEDIATED VIA CENTRAL ALPHA-ADRENORECEPTORS [J].
FINCH, L .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1975, 33 (02) :409-412
[5]  
GSCHWEND HW, Patent No. 4212808
[6]  
GSCHWEND HW, Patent No. 4187313
[7]  
HICKS PE, 1981, BRIT J PHARMACOL, V74, pP844
[8]  
KWA HY, 1979, BR J PHARM, V68, pP138
[9]   ORTHO FUNCTIONALIZATION OF N-(TERT-BUTOXYCARBONYL)ANILINE [J].
MUCHOWSKI, JM ;
VENUTI, MC .
JOURNAL OF ORGANIC CHEMISTRY, 1980, 45 (23) :4798-4801
[10]  
TIMMERMANS PBMWM, 1982, ARCH INT PHARMACOD T, V255, P321