ISOKOTANINS AC - NEW BICOUMARINS FROM THE SCLEROTIA OF ASPERGILLUS-ALLIACEUS

被引：44

作者：

LAAKSO, JA

NARSKE, ED

GLOER, JB

WICKLOW, DT

DOWD, PF

机构：

[1] UNIV IOWA,DEPT CHEM,IOWA CITY,IA 52242

[2] US AGR RES SERV,NATL CTR AGR UTILIZAT RES,PEORIA,IL 61604

来源：

JOURNAL OF NATURAL PRODUCTS | 1994年 / 57卷 / 01期

关键词：

D O I：

10.1021/np50103a018

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Three new bicoumarin metabolites, isokotanins A [1], B [2], and C [3], were isolated from the sclerotia of Aspergillus alliaceus. Isokotanin A is a regioisomer of the known bicoumarin kotanin [4]. The structures and spectral assignments for 1-3 were determined on the basis of selective INEPT, HMQC, HMBC, and NOESY nmr data, as well as by chemical interconversions. Isokotanins B and C show activity against the corn earworm Helicoverpa zea and the dried fruit beetle Carpophilus hemipterus. The known compounds kotanin [4], desmethylkotanin [5], nominine, and paspaline were also isolated from extracts of A. alliaceus sclerotia.

引用

页码：128 / 133

页数：6

共 18 条

[1]

BUCHI G, 1971, J ORG CHEM, V36, P1143

[2] A POTENT NONPEPTIDE CHOLECYSTOKININ ANTAGONIST SELECTIVE FOR PERIPHERAL-TISSUES ISOLATED FROM ASPERGILLUS-ALLIACEUS [J].