INHIBITION OF PROKARYOTIC AND EUKARYOTIC TRANSCRIPTION BY THE 2/1 2,9-DIMETHYL-1,10-PHENANTHROLINE-CUPROUS COMPLEX, A LIGAND SPECIFIC FOR OPEN COMPLEXES

被引：12

作者：

PERRIN, DM ^{[1
]}

PEARSON, L ^{[1
]}

MAZUMDER, A ^{[1
]}

SIGMAN, DS ^{[1
]}

机构：

[1] UNIV CALIF LOS ANGELES,SCH MED,INST MOLEC BIOL,DEPT CHEM & BIOCHEM,DEPT BIOL CHEM,LOS ANGELES,CA 90024

来源：

GENE | 1994年 / 149卷 / 01期

关键词：

TRANSCRIPTIONAL INHIBITORS; HIV; RNA POLYMERASE; REDOX-INACTIVE (NEOCUPCU+; OPEN COMPLEXES;

D O I：

10.1016/0378-1119(94)90426-X

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The redox-stable, tetrahedral cuprous chelate of neocuproine (2,9-dimethyl-1,10-phenanthroline) binds to the single-stranded DNA formed in open complexes and is an effective inhibitor of eukaryotic and prokaryotic transcription. Despite the many kinetic and structural differences between prokaryotic and eukaryotic transcription systems, they are all similarly inhibited by neocuproine copper, suggesting that all open complexes may share a homologous structure.

引用

页码：173 / 178

页数：6

共 38 条

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