THE DIOXIN AND PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS - NUCLEAR RECEPTORS IN SEARCH OF ENDOGENOUS LIGANDS

被引：96

作者：

POELLINGER, L

GOTTLICHER, M

GUSTAFSSON, JA

机构：

[1] Karolinska Institutet, Huddinge University Hospital F-60, S-141 86 Huddinge, Novum

[2] M. Gö, Karolinska Institutet, Huddinge University Hospital F-60, S-141 86 Huddinge, Novum

[3] Karolinska Institutet, Huddinge University Hospital F-60, S-141 86 Huddinge, Novum

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 1992年 / 13卷 / 06期

关键词：

D O I：

10.1016/0165-6147(92)90076-I

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Dioxins and peroxisome proliferators represent two diverse classes of xenobiotic compounds that induce transcription of specific genes encoding cytochrome P-450 drug-metabolizing enzymes. Signal transduction by these chemicals is mediated by two distinct nuclear receptors, one of which has recently been demonstrated to be a member of the steroid hormone receptor superfamily of ligand-activated transcription factors. However, no endogenous ligand has so far been identified for either of these nuclear receptors. Lorenz Poellinger, Martin Gottlicher and Jan-Ake Gustafsson review properties of both these xenobiotic receptor systems and discuss how the molecular details in the receptor activation pathways compare with those of nuclear hormone receptors.

引用

页码：241 / 245

页数：5

共 49 条

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